His football feats were for the Liberty AC's beginning in 1927 and he took part in many games against the rival Crescent AC. Mistretta was a fullback, who often threw touchdown passes to teammate Sam Mason, and he also drop kicked extra points.
In baseball, Mistretta played for the Jamestown Spiders, Tigers, Liberty AC and Noah's Ark. He played for over 15 years in the late 1920s and 1930s and batted over.300. He was a fine defensive catcher and among the pitchers he caught were Hugh Bedient and Swat Erickson, both former major leaguers who are Chautauqua Sports Hall of Fame inductees.
When Mistretta's baseball and football playing days were over, he remained involved in those sports by officiating.
Mistretta was also known as one of the area's top bowlers in classic leagues. His average was in the 190 to 200 range and he rolled numerous 700 series. At the age of 68, two weeks before his death, Mistretta rolled a 251 game en route to a 667 series at the Satellite Bowl.